Tan delta is a rheological property that approximates the internal friction of a material. For a reservoir patch design with an adhesive layer across the face of the entire patch, the adhesive must adhere to the membrane and provide adequate adhesion to skin, as well as be compatible with the drug and allow diffusion of the drug and any penetration enhancers to the skin interface. SSAs with varying adhesive levels can be effectively discriminated based on their rheological profiles. Biocompatible silicone adhesives, sealants, coatings and potting compounds offer elasticity, low stress, long term high temperature resistance, and superior electrically insulating properties. Silicone PSA are soluble in a variety of volatile polar and non-polar hydrocarbon solvents and additional customization may be achieved via the solvent in which the silicone PSA is dispersed as well as the concentration of the PSA in solvent. rubber coated roller to ensure complete and consistent contact between SSA and PTFE. The film was allowed to rest for 24 h after which a disc was cut from the SSA laminate using a 24 mm stainless steel punch. The characterization of PSA materials is a critical part of innovation development and production quality control. Recently, similar rheological measurements have been applied to characterize the intrinsic properties of the SSA and offer a characterization method more capable of harmonization across the industry. Dynamic frequency sweeps (0.01–100 rad/s) were conducted on dried adhesive solids using a TA ARES-G2 rheometer. Silbione™ Silicone Adhesives are solventless high strength adhesives that cure at room temperature providing a tough elastic bond. This substrate may influence the peel adhesion result due to its intrinsic elasticity and also potentially through interactions with the SSA. Identifying the true viscoelastic properties of the adhesives is critical to understand the adhesion performance of such products. This chapter will review silicone based adhesive technologies, applications and characterization, emphasizing those self-adhesive materials often used in skin contact applications. Phases can also be controlled through changing the volume fraction of silicone or acrylate through blending or addition of specific co-solvents. Gerald K. Schalau II, Alexis Bobenrieth, Robert O. Huber, Linda S. Nartker and Xavier Thomas (December 20th 2017). SSAs have become the material of choice in many advanced wound care applications, due to their reliable adhesiveness, while being easier to remove and causing less pain than many other adhesive technologies of the day. Substrate selection is important when designing an adhesive device based on SSA, as the nature of the substrate can significantly impact the coating and cure conditions during the manufacturing phase. Silicone PSA, along with acrylic and polyisobutylene (PIB) PSA, are commonly used in transdermal patch applications. This adhesive form is based on a platinum catalyzed, cross-linking reaction between vinyl functional and silicon-hydride functional silicone polymers. Optical micrograph (100X magnification) of (A) 50:50 blend of silicone PSA and non-functional acrylic PSA and (B) silicone-acrylate hybrid adhesive (50% acrylate) [20]. Silicone pressure sensitive adhesives (PSA) are comprised of high molecular weight silanol-functional silicone polymers and silanol functional MQ siloxane resins. Wound care products that utilize silicone tacky gels as the skin contact adhesive and are loaded with chlorhexidine gluconate and other antimicrobial agents have also been investigated [40]. These data coincide with observed changes in adhesive properties as plasticizing agents like IPM are added and support the further use of rheological measurements to characterize changes in wear properties. 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